fosI Is a New Integron-Associated Gene Cassette Encoding Reduced Susceptibility to Fosfomycin.
نویسندگان
چکیده
In this work, we demonstrate that the fosI gene encodes a predicted small protein with 134 amino acids and determines reduced susceptibility to fosfomycin. It raised the MIC from 0.125 to 6 μg/ml when the pBRA100 plasmid was introduced into Escherichia coli TOP10 and to 16 μg/ml when the gene was cloned into the pBC_SK(-) vector and expressed in E. coli TOP10.
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 60 1 شماره
صفحات -
تاریخ انتشار 2016